Anticardiolipin Antibody Aggravates Cerebral Vasospasm After Subarachnoid Hemorrhage in Rabbits

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Anticardiolipin antibody aggravates cerebral vasospasm after subarachnoid hemorrhage in rabbits.

BACKGROUND AND PURPOSE We previously reported that patients with antiphospholipid antibodies (aPLs) frequently demonstrate cerebral infarction due to cerebral vasospasm after subarachnoid hemorrhage (SAH). To examine the participation of aPLs in the pathogenesis of vasospasm after SAH, we studied the relationships of aPLs and SAH in an animal model. METHODS SAH was produced in 34 rabbits that...

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Vasospasm After Subarachnoid Hemorrhage

Background and Purpose—Vasospasm secondary to subarachnoid hemorrhage (SAH) is responsible for severe ischemic complications. Although effective, angioplasty must be performed at a very early stage to produce any clinical recovery. Diagnostic investigations to assess arterial narrowing (transcranial Doppler, angiography) or cerebral perfusion (xenon CT, single-photon emission CT) do not provide...

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Monoclonal antibodies against ICAM-1 and CD18 attenuate cerebral vasospasm after experimental subarachnoid hemorrhage in rabbits.

BACKGROUND AND PURPOSE Inflammatory responses have been implicated in the elaboration of several forms of central nervous system injury, including cerebral vasospasm after subarachnoid hemorrhage (SAH). A critical event participating in such responses is the recruitment of circulating leukocytes into the inflammatory site. Two of the key adhesion molecules responsible for the attachment of leuk...

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Effect of cervical sympathetic block on cerebral vasospasm after subarachnoid hemorrhage in rabbits.

PURPOSE Cerebral vasospasm (CVS) is a major complication after subarachnoid hemorrhage (SAH) induced by the rupture of intracranial aneurysms. The aim of the present study was to investigate the effect and mechanism of cervical sympathetic block on cerebral vasospasm of the rabbits after SAH. METHODS After successful modeling of cervical sympathetic block, 18 healthy male white rabbits were r...

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cerebral vasospasm following traumatic subarachnoid hemorrhage

background: cerebral vasospasm is a preventable cause of death and disability in patients who experience aneurysmal subarachnoid hemorrhage (sah). the aim of this study is to investigate the incidence of cerebral vasospasm following traumatic sah and its relationship with different brain injuries and severity of trauma. method s: this cross-sectional study was conducted from october 2006 to mar...

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ژورنال

عنوان ژورنال: Stroke

سال: 1998

ISSN: 0039-2499,1524-4628

DOI: 10.1161/01.str.29.5.1014